Who knows which villains will star in the fourth feature film, but there are a few hints out there as to which characters will be favoured. First up, in January this year, Dylan Baker, who portrays Dr. Curt Connor, said this in an interview with IGN:

IGN: Have they talked to you about becoming The Lizard in a future sequel?

Baker: Only Sam [Raimi]. Only Sam. And, of course, the whole thing is in his head. So as long as his brilliant ideas keep coming, I’ll go with him.

IGN: When Sam hired you for Spider-Man 2, did he talk to you about the character in the comics and what happens to him?

Baker: Yeah, but only in broad strokes. We’re getting a little more specific now, but it’s still pretty broad.

IGN: So you’d be up for a lot of hours in the makeup chair to add the green skin and scales?

Baker: Absolutely!

And in a more recent MTV article concerning the next movie, Raimi talked about some of the villains he would like to see:

“I would love to see Electro, Vulture, maybe the Sinister Six as a team”

Slash Film have a great feature discussing the odds and likelihood of seeing each of Spider-man’s foes. They gave The Lizard a 95% chance, Electro 73%, Hydro-man 68%, etc. with lonely Rhino at the bottom with a measly 9%.